Arsenic and Health: Diabetes

The association between arsenic exposure and diabetes mellitus has been inferred by various researchers and has received more attention due to recent epidemiological reports linking them to environmental and occupational source.  The high incidence of diabetes in Hispanic and Native American populations in both the Southwestern U.S. and Northern Mexico could, in part, be explained by their exposure to arsenic via drinking water.  The high prevalence of diabetes, the presence of adverse polymorphisms in arsenic biotransformation genes, and high levels of arsenic exposure in some areas of the U.S.-Mexico Border suggest the need to study the interactions among these factors.

The objective of this study is to explore, in human and experimental models, the relationships between arsenic exposure and diabetes relative to calpain polymorphisms, alterations of calpain expression, and activity of annexin II and plasmin regulation.

Principal investigators have identified populations with high arsenic exposure and are relating the exposure toincidences of diabetes to polymorphisms of key genes implicated in a higher sensitivity.  Results from the project will be used to help define what measures can be taken in the community to lower diabetes risk.

 

 

Project Contacts:

Dr. A. Jay Gandolfi
The University of Arizona
Principal Investigator – U.S.
gandolfi@pharmacy.arizona.edu
Dr. Walter Klimecki
The University of Arizona
Principal Investigator – U.S.
walt@resp-sci.arizona.edu

Dr. Patricia Ostrosky

Universidad Nacional Autonoma de Mexico

Principal Investigator - Mexico

ostrosky@servidor.unam.mx

Dr. Mariano E. Cebrian Garcia
Centro de Investigación y de Estudios Avanzados
Principal Investigator – Mexico
mcebrian@cinvestav.mx

Dr. Gonzalo Garcia Vargas
Universidad Juarez del Estado de Durango

Investigator – Mexico
ggarcia_vargas@hotmail.com

Dr. Lizbeth Teresita Lopez Carrillo
Instituto Nacional de Salud Publica
Investigator - Mexico
lizbeth@insp.mx

Dr. Marcia V. Galvan-Portillo

Instituto Nacional de Salud Publica

Investigator - Mexico

mgalvan@correo.insp.mx